Breast: Risk Models
Gail Model
Basics
- Calculates Risk of Breast Cancer In 5 Years & In Lifetime
- May Underestimate the Risk
Factors
- Age
- Age of Menarche
- Age of First Full-Term Pregnancy
- Number of Past Breast Biopsies
- Personal History of Atypical Hyperplasia (ALH/ADH)
- Number of First-Degree Relatives with Breast Cancer
- Race/Ethnicity
Tyrer-Cuzick Model (IBIS Tool)
Basics
- IBIS: International Breast Cancer Intervention Study
- Calculates Risk of Breast Cancer In 10 Years & In Lifetime
- May Overestimate Risk & Is Generally Higher Than Other Models
Factors
- Age
- Height
- Weight
- Age of Menarche
- Parity & Age of First Full-Term Pregnancy
- Menopausal Status
- History of Hormone Replacement Therapy & Length of Use
- BRCA Status
- History of Breast Biopsy
- History of Hyperplasia, Atypia or Carcinoma In-Situ
- History of Ovarian Cancer
- BI-RADS ATLAS Breast Density
- Ashkenazi Inheritance
- Family History of Breast Cancer, Age or Age at Death, Ovarian Cancer, BRCA Status
- Also Considers Family Beyond the First-Degree
Other Models
Claus Model
- Includes More Family History of Breast Cancer Than the Gail Model
- Does Not Include Other Personal Information (Age of Menarche, Number of Biopsies, etc.) That Are Included in the Gail Model
BRCAPRO Model
- Includes More Family History of Breast Cancer Than the Gail Model
- Includes Family History of Ovarian Cancer
- Includes History of Oophorectomy
- Calculates Risk of Breast & Ovarian Cancers
BOADICEA Model
- Calculates Risk of Breast & Ovarian Cancers
- Also Calculates Risk of Carrying BRCA Mutations