Skin & Soft Tissue: Epidermoid Cyst Epidermoid Cyst DefinitionAlso Known as “Epidermal Inclusion Cyst” & “Sebaceous Cyst”Benign Keratin Containing Cavity Surrounded by a Cystic Wall of Stratified Squamous EpitheliumMost Common Skin CystPresentationDermal NoduleSkin ColoredMay Have a Central PunctumOccur Anywhere Over the BodyCan Rupture (Cause Inflammation & Pain)Can Become Infected (Fluctuant, Erythematous, Painful & Purulent)DiagnosisMostly Clinical (Based on History and Physical Exam) Epidermoid Cyst 1 Inflamed Epidermoid Cyst 2 TreatmentAsymptomatic: NothingSymptomatic or Patient Preference (Cosmesis): ExcisionFailure to Remove Entire Cyst Wall Significantly Increases Risk of RecurrenceAcutely Inflamed or Infected: Incision & Drainage (I&D)Excision Difficult When Inflamed Because Wall is Very Friable Epidermoid Cyst Excision 3 References Peter KD. Wikimedia Commons. (License: CC BY-3.0)Fruitsmaak S. Wikimedia Commons. (License: CC BY-SA-3.0)SF. Wikimedia Commons. (License: CC BY-SA-3.0)