Breast: Fibrocystic Change/Disease Fibrocystic Change/Disease DefinitionDefinition: A Heterogenous Group of Benign Non-Proliferative LesionsThe Most Common Benign Breast EntityAssociated with Increased Estrogen, Progesterone & ProlactinRarely Seen Post-MenopausePresentationBilateralCyclic Breast PainTender Nodular Breast Tissue – May Vary with CycleMost Common in the Upper Outer QuadrantMay Have Yellow or Green Nipple DischargeDiagnosisConsider Imaging (Mammogram/US) & Core Needle Biopsy as Indicated for Suspicious Lesions*See Breast: Breast Mass EvaluationTreatmentNo Treatment Required if No Suspicious Lesions are identified Fibrocystic Changes 1 Fibrocystic Changes, Gross Pathology 2 Fibrocystic Changes, Histology 3 References Mekuix. Wikimedia Commons. (License: CC BY-SA-4.0)University of Liverpool. Wikimedia Commons. (License: CC BY-SA-2.0)Nephron. Wikimedia Commons. (License: CC BY-SA-3.0)