Endocrine: Hypoparathyroidism

Hypoparathyroidism

• Definition: Insufficient PTH Secretion
• Can Cause Significant Hypocalcemia
• Causes:
  • Postoperative from Thyroid or Parathyroid Surgery (Most Common)
    • Often Transient but Can Be Permanent
  • Autoimmune
  • Genetic
• Diagnosis/Labs:
  • Low PTH
  • Low Calcium
  • High Phosphate
• Treatment: Calcium & Vitamin D Supplementation
  • Recombinant Human PTH (rhPTH) May Assist in Long-Term Management of Chronic Disease

Pseudohypoparathyroidism

• Definition: Hereditary Inadequate Response to PTH
  • Resistance Largely Occurs in the Kidneys
• Mutations: GNAS or STX16
• Albright Hereditary Osteodystrophy
  • A Group of Symptoms Associated with Pseudohypoparathyroidism
  • Presentation: Short Stature, Obese, Round Face & Brachydactyly (Shortened Digits)
• More Common in Females (2:1)
• Labs:
  • Low Calcium
  • High Phosphorous
  • High PTH
• Treatment: Calcium & Vitamin D Supplementation