Skin & Soft Tissue: Lipoma Lipoma BasicsBenign Tumor of Adipose Tissue with a Thin Fibrous CapsuleMost Common in the Subcutaneous TissueCan Involve Fascia or Deeper Muscle PlanesThe Most Common Mesenchymal TumorFamilial Multiple Lipomatosis – Genetic Condition Associated with Numerous LipomasPresentationSoft Mobile LesionCan Be Round or MultilobulatedNormal Overlying SkinMostly Painless but Can Be Associated with PainMost Common on Trunk and Upper ExtremitiesCan be Single or MultipleDiagnosisClinical (Based on History and Physical Exam)TreatmentAsymptomatic: No Treatment RequiredIndications for Surgical Excision:PainConcern for MalignancyPatient Preference (Cosmesis) Lipoma 1 Multiple Lipoma Excision 2 References Iqbal S. Wikimedia Commons. (License: CC BY-3.0)JR3336. Wikimedia Commons. (License: CC BY-SA-4.0)