Skin & Soft Tissue: Trichilemmal (Pilar) Cyst Trichilemmal (Pilar) Cyst BasicsBenign Proliferation from the Hair Follicle Root SheathContain Keratin from Follicles, No EpidermisPresentationSlow Growing Subcutaneous NoduleNormal Overlying SkinMost Common on the ScalpPhysically Resemble Epidermoid CystsDiagnosisHistology Generally Required to Differentiate from Epidermoid CystsTreatmentAsymptomatic: NothingSymptomatic or Patient Preference (Cosmesis): ExcisionFailure to Remove Entire Cyst Wall Significantly Increases Risk of RecurrenceGenerally Easier to Remove than Epidermoid Cysts (Thicker Wall) Trichilemmal Cyst 1 Trichilemmal Cyst Histology 2 References Northern Cedar. Wikimedia Commons. (License: CC BY-SA-3.0)Haggstrom M. Wikimedia Commons. (License: Public Domain)