Biliary Tract: Anatomy & Physiology

Anatomy

Normal Sizes

  • CBD < 6-8 mm
    • 10 mm After Cholecystectomy
    • Increases 1 mm Every 10 Years After Age 60
  • Gallbladder Wall < 4 mm
  • Pancreatic Duct < 4 mm

Gallbladder Anatomy

  • Structure
    • Fundus – Round Distal Projection
    • Body – Largest Portion
    • Neck – Tapered Portion Continuous with Cystic Duct
  • Layers
    • Mucosa – Columnar Epithelium
    • No Submucosa
  • Gallbladder Lies Beneath Liver Segments IV/V

Biliary Tract

  • Left & Right Hepatic Ducts Combine to Form Common Hepatic Duct (CHD)
    • Left Haptic Duct is Longer Than Right
    • Left Haptic Duct is More Likely to Dilate in Distal Obstruction
  • Cystic Duct Enters Common Hepatic Duct to Form Common Bile Duct (CBD)
    • Heister Valve – Spiral Valves in Cystic Duct with No Valve Function
  • CBD & Pancreatic Duct Unite Outside Duodenal Wall
    • Traverse Wall as Single Duct
  • Sphincter of Oddi
    • Muscular Fibers within Wall of Duodenum Around Ampulla of Vater
    • Components
      • Sphincter Choledochus (Sphincter of Boyden) – Encircles CBD
      • Sphincter Pancreaticus – Encircles Pancreatic Duct
        • Interlocks with Sphincter Choledochus to form Figure-of-Eight

Accessory Structures

  • Rokitansky-Aschoff Sinuses
    • Epithelial Invaginations in Gallbladder Wall
    • From Increased Pressure (Chronic Cholecystitis)
  • Ducts of Luschka
    • Accessory Bile Ducts in Gallbladder Fossa
    • Can Leak After Cholecystectomy

Vascular Supply

  • Gallbladder
    • Cystic Artery – Off Right Hepatic Artery
      • Found in Triangle of Calot
      • Branches: Superficial & Deep
    • Cystic Vein – Into Right Branch of Portal Vein
  • CBD
    • Marginal Arteries at 3-o’clock and 9-o’clock on ERCP
    • Supply
      • Lateral Portion (Proximal): Right Hepatic Artery
      • Medial Portion (Distal): GDA (Retroduodenal Branches)

Lymphatics

  • Lie to the Right of CBD

Nerves

  • Parasympathetics – Left Vagus Trunk (Anterior)
  • Sympathetics – Splanchnic & Celiac Ganglions

Triangle of Calot

  • Borders:
    • Lateral: Cystic Duct
    • Medial: Common Hepatic Duct
    • Superior: Liver
  • Contents:
    • Cystic Artery
    • Node of Calot (Cystic Node)
      • First Site of Mets
  • Rouviere’s Sulcus – Naturally Occurring Cleft in the Right Lobe of the Liver, Anterior to Segment 1
    • Used as Landmark to Begin Dissection of Calot’s Triangle
    • Present in 80% of Normal Livers

Aberrant Anatomy

  • Biliary System:
    • Anatomic Variation Frequency: 30-40%
    • Most Variable Course: Right Posterior Hepatic Duct
    • Anomalies:
      • Trifurcation: Right Posterior Joins with Right Anterior & Left Hepatic Ducts Together (10-11%)
      • Crossover Anomaly: Right Posterior Joins with Left Hepatic Duct (11-15%)
        • Most Common Anomaly
      • Other Anomalies:
        • Right Posterior Joins with Common Hepatic Duct (6%)
        • Right Posterior Joins with Cystic Duct (2%)
        • Right Hepatic Duct Drains into the Cystic Duct
        • Accessory Hepatic Ducts
      • *Multiple Different Classification Systems with Different Types Have Been Proposed
  • Vascular System:
    • Cystic Artery Origin Variations: Common Hepatic, Gastroduodenal or SMA
    • Double Cystic Arteries Seen in 10%

Gallbladder & Biliary Tract Anatomy 1

Blood Supply of the Biliary Tract

Triangle of Calot 2

Rouviere’s Sulcus

Physiology

Bilirubin

  • Production
    • Hgb Breakdown > Heme > Biliverdin > Unconjugated Bilirubin
    • Unconjugated Bilirubin
      • Conjugated in Liver by Glucuronyl Transferase (Adds Glucuronic Acid)
    • Conjugated Bilirubin
      • Increased Water Solubility & Secreted in Bile
  • Gut
    • Conjugated Bilirubin > Urobilinogen > Stercobilinogen > Stercobilin
      • Breakdown by Bacteria in Terminal Ileum
    • Urobilinogen – Reabsorbed
    • Stercobilin – Brown Color of Stool
  • Reabsorption
    • Site
      • Unconjugated: Passively in Small Intestine & Colon
      • Conjugated: Actively in Terminal Ileum
    • Urobilinogen > Urobilin
    • Urobilin – Yellow Color of Urine
  • Delta Bilirubin
    • Conjugated Bilirubin Bound to Albumin
    • 18 Day Half-Life – Long Time to Clear When Chronically Elevated

Bile Contents

  • Water (97%)
    • Rapid Concentration
    • NaCl – Active Absorption (Na/K ATPase)
    • Water – Passive Resorption
  • Bile Salts (0.7%)
    • Function: Emulsifies Fat, Forming Micelles
    • Bile Acids
      • Source: Cholesterol Breakdown
      • Primary Bile Acids
        • Cholic & Chenodeoxycholic Mn
        • Produced in Liver
      • Secondary Bile Acids
        • Deoxycholic & Lithocholic
        • Transformed by Bacteria in Gut
        • Recycled Through Enterohepatic Circulation
    • Bile Salt: Bile Acid (Primary or Secondary) Conjugated with Taurine & Glycine
      • Improve Water Solubility
      • Allow Secretion in Bile
    • Cholecystectomy Effects:
      • Minimal Effect on Bile Acid Secretion
      • Increased Enterohepatic Bile Salt Circulation
  • Fats (0.5%)
    • Lecithin
      • Phospholipid
      • Function: Emulsifies Fat & Solubilizes Cholesterol
    • Cholesterol
    • Fatty Acids
  • Bilirubin (0.2%)
    • *See Above
  • Inorganic Salts

Hormones

  • Bile Excretion
    • Increased: Secretin #1, CCK, Parasympathetic (Vagus) Input
    • Decreased: Somatostatin, Sympathetic (Splanchnic) Input
  • Gallbladder Contraction
    • CCK: Constant/Steady Contraction
    • Motilin: Stimulates Contraction in Fasting State
    • Parasympathetic (Vagus) Input Stimulates Contraction
  • Sphincter of Oddi Control
    • Morphine: Contracts
    • Glucagon: Relaxes
  • *See General Abdomen: GI Hormones

Mnemonic

Primary vs Secondary Bile Salts

  • “C-Comes First”
    • Cholic & Chenodeoxycholic are Primary Bile Salts
    • Deoxycholic & Lithocholic are Secondary Bile Salts

References

  1. Wikimedia Commons (License: CC BY-SA-4.0)
  2. Perera E, Bhatt S, Dogra VS. Cystic duct remnant syndrome. J Clin Imaging Sci. 2011;1:2. (License: CC BY-NC-SA-3.0)