Biliary Tract: Anatomy & Physiology
Anatomy
Normal Sizes
- CBD < 6-8 mm- 10 mm After Cholecystectomy
- Increases 1 mm Every 10 Years After Age 60
 
- Gallbladder Wall < 4 mm
- Pancreatic Duct < 4 mm
Gallbladder Anatomy
- Structure- Fundus – Round Distal Projection
- Body – Largest Portion
- Neck – Tapered Portion Continuous with Cystic Duct
 
- Layers- Mucosa – Columnar Epithelium
- No Submucosa
 
- Gallbladder Lies Beneath Liver Segments IV/V
Biliary Tract
- Left & Right Hepatic Ducts Combine to Form Common Hepatic Duct (CHD)- Left Haptic Duct is Longer Than Right
- Left Haptic Duct is More Likely to Dilate in Distal Obstruction
 
- Cystic Duct Enters Common Hepatic Duct to Form Common Bile Duct (CBD)- Heister Valve – Spiral Valves in Cystic Duct with No Valve Function
 
- CBD & Pancreatic Duct Unite Outside Duodenal Wall- Traverse Wall as Single Duct
 
- Sphincter of Oddi- Muscular Fibers within Wall of Duodenum Around Ampulla of Vater
- Components- Sphincter Choledochus (Sphincter of Boyden) – Encircles CBD
- Sphincter Pancreaticus – Encircles Pancreatic Duct- Interlocks with Sphincter Choledochus to form Figure-of-Eight
 
 
 
Accessory Structures
- Rokitansky-Aschoff Sinuses- Epithelial Invaginations in Gallbladder Wall
- From Increased Pressure (Chronic Cholecystitis)
 
- Ducts of Luschka- Accessory Bile Ducts in Gallbladder Fossa
- Can Leak After Cholecystectomy
 
Vascular Supply
- Gallbladder- Cystic Artery – Off Right Hepatic Artery- Found in Triangle of Calot
- Branches: Superficial & Deep
 
- Cystic Vein – Into Right Branch of Portal Vein
 
- Cystic Artery – Off Right Hepatic Artery
- CBD- Marginal Arteries at 3-o’clock and 9-o’clock on ERCP
- Supply- Lateral Portion (Proximal): Right Hepatic Artery
- Medial Portion (Distal): GDA (Retroduodenal Branches)
 
 
Lymphatics
- Lie to the Right of CBD
Nerves
- Parasympathetics – Left Vagus Trunk (Anterior)
- Sympathetics – Splanchnic & Celiac Ganglions
Triangle of Calot
- Borders:- Lateral: Cystic Duct
- Medial: Common Hepatic Duct
- Superior: Liver
 
- Contents:- Cystic Artery
- Node of Calot (Cystic Node)- First Site of Mets
 
 
- Rouviere’s Sulcus – Naturally Occurring Cleft in the Right Lobe of the Liver, Anterior to Segment 1- Used as Landmark to Begin Dissection of Calot’s Triangle
- Present in 80% of Normal Livers
 
Aberrant Anatomy
- Biliary System:- Anatomic Variation Frequency: 30-40%
- Most Variable Course: Right Posterior Hepatic Duct
- Anomalies:- Trifurcation: Right Posterior Joins with Right Anterior & Left Hepatic Ducts Together (10-11%)
- Crossover Anomaly: Right Posterior Joins with Left Hepatic Duct (11-15%)- Most Common Anomaly
 
- Other Anomalies:- Right Posterior Joins with Common Hepatic Duct (6%)
- Right Posterior Joins with Cystic Duct (2%)
- Right Hepatic Duct Drains into the Cystic Duct
- Accessory Hepatic Ducts
 
- *Multiple Different Classification Systems with Different Types Have Been Proposed
 
 
- Vascular System:- Cystic Artery Origin Variations: Common Hepatic, Gastroduodenal or SMA
- Double Cystic Arteries Seen in 10%
 

Gallbladder & Biliary Tract Anatomy 1

Blood Supply of the Biliary Tract

Triangle of Calot 2

Rouviere’s Sulcus
Physiology
Bilirubin
- Production- Hgb Breakdown > Heme > Biliverdin > Unconjugated Bilirubin
- Unconjugated Bilirubin- Conjugated in Liver by Glucuronyl Transferase (Adds Glucuronic Acid)
 
- Conjugated Bilirubin- Increased Water Solubility & Secreted in Bile
 
 
- Gut- Conjugated Bilirubin > Urobilinogen > Stercobilinogen > Stercobilin- Breakdown by Bacteria in Terminal Ileum
 
- Urobilinogen – Reabsorbed
- Stercobilin – Brown Color of Stool
 
- Conjugated Bilirubin > Urobilinogen > Stercobilinogen > Stercobilin
- Reabsorption- Site- Unconjugated: Passively in Small Intestine & Colon
- Conjugated: Actively in Terminal Ileum
 
- Urobilinogen > Urobilin
- Urobilin – Yellow Color of Urine
 
- Site
- Delta Bilirubin- Conjugated Bilirubin Bound to Albumin
- 18 Day Half-Life – Long Time to Clear When Chronically Elevated
 
Bile Contents
- Water (97%)- Rapid Concentration
- NaCl – Active Absorption (Na/K ATPase)
- Water – Passive Resorption
 
- Bile Salts (0.7%)- Function: Emulsifies Fat, Forming Micelles
- Bile Acids- Source: Cholesterol Breakdown
- Primary Bile Acids- Cholic & Chenodeoxycholic Mn
- Produced in Liver
 
- Secondary Bile Acids- Deoxycholic & Lithocholic
- Transformed by Bacteria in Gut
- Recycled Through Enterohepatic Circulation
 
 
- Bile Salt: Bile Acid (Primary or Secondary) Conjugated with Taurine & Glycine- Improve Water Solubility
- Allow Secretion in Bile
 
- Cholecystectomy Effects:- Minimal Effect on Bile Acid Secretion
- Increased Enterohepatic Bile Salt Circulation
 
 
- Fats (0.5%)- Lecithin- Phospholipid
- Function: Emulsifies Fat & Solubilizes Cholesterol
 
- Cholesterol
- Fatty Acids
 
- Lecithin
- Bilirubin (0.2%)- *See Above
 
- Inorganic Salts
Hormones
- Bile Excretion- Increased: Secretin #1, CCK, Parasympathetic (Vagus) Input
- Decreased: Somatostatin, Sympathetic (Splanchnic) Input
 
- Gallbladder Contraction- CCK: Constant/Steady Contraction
- Motilin: Stimulates Contraction in Fasting State
- Parasympathetic (Vagus) Input Stimulates Contraction
 
- Sphincter of Oddi Control- Morphine: Contracts
- Glucagon: Relaxes
 
- *See General Abdomen: GI Hormones
Mnemonic
Primary vs Secondary Bile Salts
- “C-Comes First”- Cholic & Chenodeoxycholic are Primary Bile Salts
- Deoxycholic & Lithocholic are Secondary Bile Salts
 
References
- Wikimedia Commons (License: CC BY-SA-4.0)
- Perera E, Bhatt S, Dogra VS. Cystic duct remnant syndrome. J Clin Imaging Sci. 2011;1:2. (License: CC BY-NC-SA-3.0)