Large Intestine: Inflammatory Bowel Disease (IBD)

Inflammatory Bowel Disease (IBD)

Crohn’s Disease

Ulcerative Colitis (UC)

Inflammatory Bowel Disease Type Unspecified (Indeterminate Colitis)

  • Definitions:
    • Inflammatory Bowel Disease Type Unspecified – Clinically Unable to Differentiate Crohn’s Disease or Ulcerative Colitis Based on Presentation, Endoscopy or Biopsy
    • Indeterminate Colitis – Originally a Pathology Term for Histology that was Unable to Differentiate Crohn’s Disease or Ulcerative Colitis
      • Has Been Adapted & Often Used Interchangeably for a Clinical Inability to Differentiate
  • Accounts for 10% of IBD Patients

Comparison

  Crohn’s Disease Ulcerative Colitis
Continuity Skip Lesions Continuous
Location Mouth to Anus Colon from Rectum (Spares Anus)
Thickness Transmural Mucosa & Submucosa
Morphology Ulceration, Fissure, Cobblestone Mucosa, Creeping Fat & Noncaseating Granulomas Ulceration, Friable Mucosa & Crypt Abscess
Surrounding Mucosa Normal Pseudopolyps
Complications Abscess, Fistula, SBO & Fibrosis GI Bleed, Backwash Ileitis, Toxic Colitis & Toxic Megacolon
Extraintestinal Manifestations Arthritis, Rash, Eye Complications & Kidney Stones Arthritis, Rash, Eye Complications, Primary Sclerosing Cholangitis & VTE
Smoking Increased Risk Protects